Phenibut HCL 99.99%

Phenibut HCL
What is Phenibut?
β-Phenyl-γ-aminobutyric acid, better known as “Phenibut” is a direct analogue of the naturally occurring neurotransmitter γ-aminobutyric acid, also known as GABA, a vital monoamine transmitter produced by our own bodies. Phenibut is a syntheticaromatic amino acid. It is a chiral molecule and thus has two potential configurations, as (R)- and (S)-enantiomers; generally, for medicinal purposes, the R-isomer is preferred due to it’s higher affinity too relevant binding sites. GABA is responsible for protecting neurons from toxicity, over-excitement, and regulating the central nervous system. Phenibut, which acts on specific GABA-B binding sites has a recent medical history in successfully treating a host of problematic health issues such as mood disorders, seizure disorders, and has even shown it’s ability too treat physical dependence on other gabaergic substances such as alcohol and benzodiazpenes.

Neurochemistry and Pharmacology
On a neurochemical level, phenibut acts by up-regulating the presence of GABA, which is then sent too GABA-B receptors at 85 known binding sites, where they are agonized, providing neuroprotective properties, and regulation of vital nervous system functions that certain patients may struggle too naturally ordinate. While little conclusive evidence exists too substantiate this claim, it appears treatment of certain disorders using this potential medicine would not require the patient take it daily, suggesting a long, gentle half-life of metabolites and their utilization. When cessation of the substance is being considered, it is remarkably safer too discontinue than it’s chemical cousins such as benzodiazpenes, alcohol, or GHB.

Chemistry
As previously mentioned, Phenibut is a syntheticaromatic amino acid. This makes it a direct analogue of the neurotransmiter GABA itself, again, being a chiral molecule it has two potential configurations, as (R)- and (S)-enantiomers. The only difference between phenibut as a compound and the naturally occuring monoamine transmitter GABA, is a a phenyl ring substituted in at the β-position. This simply allows it too pass the blood brain barrier, unlike GABA in it’s pure form.
Potential for addiction and dependence
It’s potential for addiction is the same as anything in this world; providing a subtle and well-tolerated binding profile, the likelihood of addiction is present, but not of high risk. Physical dependence seems too only occur in those who abuse the compound heavily and frequently, well beyond the prescribed amount in the countries it is currently medicinally recognized. However, even in the case of physical dependence, symptomatic excitotoxicity and the down-regulation of GABA is significantly less impactful than that of it’s chemical cousins, and is generally well tolerated, especially when using taperage methods too discontinue use. It is not known too cause neuron-death, or damage too GABA receptors. It’s toxicology profile is very mild, and generally only problematic in it’s hydrochloride salt form. It may cause irritation too the digestive tract due too hydrochloric acid’s natural caustic properties, and is therefore rarely used to begin with. There is no known LD-50 (lethal dose) associated with Phenibut.

Phenibut as an alternative too benzodiazpenes
Ultimately, as a treatment for mood and seizure disorders, addictions, and many other neurotoxic medical conditions, Phenibut shows remarkably safer, more effective, and less abusable properties than the standard benzodiazpenes that the medical system has come too rely on. Covered in this short writeup exists plenty of explanations as too why one might consider prescribing this medication over something such as clonazepam, diazepam, or any other sedative-hypnotic that can cause the death of vital neurotransmitter receptors, gruesome and unmanageable withdrawal symptoms, and loss of mood regulation. It is up to us as researchers too provide analytical data for review, so that one day Health Canada may recognize this as a potential medicine to go under clinical trials.

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